Table 4.
GRADE evidence profile Table for PICO 5.
| Question: Permissive or induced hypertension compared to conventional blood pressure (BP) management (target normotension) for outcome | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Setting: patients with an acute ischemic stroke or transient ischemic attack related to a high-grade intracranial atherostenosis causing severe hemodynamic compromise. | ||||||||||||
| Certainty assessment | No. of patients | Effect | Certainty | Importance | ||||||||
| No. of studies | Study design | Risk of bias | Inconsistency | Indirectness | Imprecision | Other considerations | Permissive or induced hypertension | conventional blood pressure (BP) management (target normotension) | Relative (95% CI) | Absolute (95% CI) | ||
| Mortality | ||||||||||||
| 1 | Randomized trials | Not serious | Not serious | Not serious | Serious a | None | 0/59 (0.0%) | 0/52 (0.0%) | Not estimable | ⨁⨁⨁◯ Moderate |
CRITICAL | |
CI: confidence interval.
a
RCT not adequately powered compared to required sample size calculation.