TABLE 1.

Cumulative diffuse alveolar damage score and its components, alveolar heterogeneity index, and perivascular edema

	CF		LF
	PCV	PSV	PCV	PSV
Axial parenchyma
Edema (cuff) (0–16)	2 (1–4)	3 (1–4)	2 (2–2.5)	10 (7–12) # , †
Inflammatory infiltrate (0–16)	3.5 (3–6.8)	3 (1.75–4)	4 (3.8–4.5)	3 (2–4)
Alveolar parenchyma
Edema intra‐alveolar (0–16)	3 (1–4)	1 (0–2)	1.5 (0.8–2.5)	10.5 (8–13) # , †
Inflammatory infiltrate (0–16)	3.5 (2.8–4)	4 (2–4)	2.5 (1–4)	3 (2–3.8)
Cumulative DAD score (0–64)	13 (10.3–15.8)	10 (7.8–12)	9 (7.8–11.3)	25 (23–31.5) # , †
β (D 2/Lm)	1.29 (1.21–1.42)	1.26 (1.19–1.50)	1.32 (1.24–1.52)	1.20 (1.07–1.31)
Perivascular edema	0.62 (0.54–0.68)	0.57 (0.52–0.62)	0.83 (0.63–0.85)*	0.71 (0.64–0.84) #

Note: Values are presented as the median (interquartile range [25%–75%]) of 6 animals per group. Comparisons were performed by Kruskal–Wallis test followed by Dunn's multiple comparison test (p < 0.05).

Abbreviations: CF, conservative fluid therapy; DAD, diffuse alveolar damage; LF, liberal fluid therapy; PCV, pressure‐controlled ventilation; PSV, pressure‐support ventilation; β, alveolar heterogeneity index.

^* p < 0.05 significantly different from CF‐PCV.

^# p < 0.05 significantly different from CF‐PSV.

^† p < 0.05 significantly different from LF‐PCV.