Figure 2.

Cross-talk between MAPK and mTOR signaling pathways. Schematic representation of MAPK and mTOR signaling pathways upon growth factor activation. Arrows represent activation, while t-shaped lines represent inhibition. Black lines depict signaling within a pathway. Red lines depict crosstalk between signaling pathways. TSC1/2: tuberous sclerosis 1/2; 4EBP1: eukaryotic translation initiation factor 4E-binding protein 1; P: phosphorylation; pS6: phosphorylated S6; GDP: guanosine diphosphate; GTP: guanosine triphosphate