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. 2022 Aug 19;10:870193. doi: 10.3389/fbioe.2022.870193

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Copyright © 2022 Thomas, Fahey, Pugliese, Irwin, Antonyak and Delco.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A subset of MitoEVs contain functional mitochondria. (A) Representative flow plot identifying polarized mitoEVs; events fluorescing above control thresholds for calcein AM (green) and TMRM (orange) were classified as mitoEVs containing functional MT (red). (B). Quantification of functional mitoEVs (red-green double positive events) and three control groups; TMRM only (▴), calcein only (■), and unstained control (▾), compared to EVs stained with calcein + TMRM (●). Data is expressed as the fraction of double-positive events in each group. of percent red/green double positive showed statistically significant differences between the double stained experimental group and single color/unstained controls Groups that do not share a letter are significantly different (n = 3, p ≤0.05) by one-way ANOVA.