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. 2022 Aug 23;13:921287. doi: 10.3389/fendo.2022.921287

Table 3.

Subgroup analyses for association between blood hemoglobinA1c and HRV by adding “CVD history” as stratification variables.

Variables n LF-HRV HF-HRV
95% CI P Value P # 95% CI P Value P #
Ever had DM (YES) 108 -0.097 (-0.177, -0.017) 0.019 0.029 -0.118 (-0.208, -0.027) 0.012 0.019
Ever had DM (NO) 820 0.043 (-0.103, 0.189) 0.565 0.095 (-0.059, 0.248) 0.228
Ever had heart disease (YES) 84 -0.102 -0.337, 0.134 0.392 0.901 -0.058 -0.305, 0.189 0.643 0.916
Ever had heart disease (NO) 884 -0.091 -0.154, -0.029 0.004 -0.072 -0.138, -0.006 0.032
Ever had hypertension (YES) 318 -0.133 -0.239, -0.027 0.014 0.419 -0.102 -0.210, 0.007 0.066 0.854
Ever had hypertension (NO) 610 -0.047 -0.122, 0.027 0.210 -0.043 -0.122, 0.035 0.278
Ever had TIA or stroke (YES) 30 -0.468 -0.882, -0.053 0.029 0.063 -0.343 -0.743, 0.058 0.090 0.172
Ever had TIA or stroke (NO) 898 -0.070 -0.132, -0.009 0.025 -0.044 -0.109, 0.021 0.185
Ever had cholesterol problems (YES) 394 -0.166 -0.210, -0.023 0.015 0.904 -0.095 -0.194, 0.004 0.059 0.464
Ever had cholesterol problems (NO) 534 -0.059 -0.140, 0.022 0.156 -0.023 -0.109, 0.062 0.593

Adjusted for age, gender, BMI, ever smoker, number of drinking years and exercise.

P#: P interaction.

DM, diabetes mellitus; CVD, cardiovascular disease; LF-HRV, low frequency-heart rate variability; HF-HRV, High frequency heart rate variability; TIA, transient ischemic attack; BMI, body mass index.