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. Author manuscript; available in PMC: 2022 Sep 6.

Published in final edited form as: Biochem Pharmacol. 2017 Feb 15;131:68–77. doi: 10.1016/j.bcp.2017.02.006

Rev-erbα represses transcription of cholesterol biosynthesis pathway genes. a) Comparison of global run-on sequencing (GRO-seq) signals from mouse liver between Rev-erbα deficient (KO) mice and wild-type (WT) mice. b) Comparison of GRO-seq signals from mouse liver between ZT10 and ZT22 time points in wild-type C57Bl/6J mice. c) Comparison of genes bound and repressed by Rev-erb based on ChIP-seq and GRO-seq results. d) Normalized GRO-seq signals of cholesterol biosynthesis pathway genes in Rev-erbα KO vs. WT mice at ZT22. e) Analysis of available HDAC3 and NCoR ChIP-Seq datasets derived from mouse liver at ZT10 and ZT22 time points.

Rev-erbα represses transcription of cholesterol biosynthesis pathway genes. a) Comparison of global run-on sequencing (GRO-seq) signals from mouse liver between Rev-erbα deficient (KO) mice and wild-type (WT) mice. b) Comparison of GRO-seq signals from mouse liver between ZT10 and ZT22 time points in wild-type C57Bl/6J mice. c) Comparison of genes bound and repressed by Rev-erb based on ChIP-seq and GRO-seq results. d) Normalized GRO-seq signals of cholesterol biosynthesis pathway genes in Rev-erbα KO vs. WT mice at ZT22. e) Analysis of available HDAC3 and NCoR ChIP-Seq datasets derived from mouse liver at ZT10 and ZT22 time points.