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Global analysis of functional and direct target genes of Rev-erbα. Comparison of genes bound and repressed by Rev-erbα, based on ChIP-Seq and GRO-Seq results, revealed 6012 functional and direct target genes of Rev-erbα. Gene-Ontology analysis indicated that these genes were enriched with genes involved in the regulation of cholesterol biosynthesis, and that perturbation of these genes is associated with cholesterol related abnormal mouse phenotype and human disease.
