Table 2.
Description of methylation-based measures
| Methylation-based measures | MCCS | EPIC-IARC | EPIC-Italy | PLCO | ||||
|---|---|---|---|---|---|---|---|---|
| Median (IQR) | R2,* (%) | Median (IQR) | R2,* (%) | Median (IQR) | R2,* (%) | Median (IQR) | R2,* (%) | |
| Horvath age | 54 (47; 60) | 49 | 51 (44; 57) | 60 | 52 (46; 57) | 64 | 65 (62; 69) | 39 |
| Hannum age | 62 (55; 68) | 59 | 53 (46; 60) | 64 | 59 (53.6; 62.9) | 72 | 56 (52; 59) | 48 |
| PhenoAge | 54 (46; 61) | 39 | 44 (36; 51) | 50 | 42 (35; 48) | 56 | 51 (47; 56) | 32 |
| GrimAge | 53 (48; 57) | 66 | 52 (47; 57) | 69 | 59 (55; 63) | 62 | 46 (42; 50) | 50 |
| BMI score | 0.0 (−0.6; 0.7) | 16 | 0.0 (−0.7; 0.7) | 14 | −0.1 (−0.6; 0.7) | 18 | 0.0 (−0.7; 0.6) | 22 |
| Smoking score | −0.2 (−0.6; 0.3) | 41 | −0.4 (−0.6; 0.1) | 44 | −0.4 (−0.6; 0.2) | 54 | −0.3 (−0.6; 0.2) | 41 |
| Alcohol score | −0.1 (−0.6; 0.6) | 3 | −0.1 (−0.7; 0.6) | 7 | −0.1 (−0.6; 0.6) | 3 | −0.1 (−0.6; 0.5) | 9 |
MCCS Melbourne Collaborative Cohort Study; EPIC European Prospective Investigation into Cancer and Nutrition; IARC International Agency for Research on Cancer; PLCO Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial; IQR Interquartile range
*Variance explained of age, BMI, smoking and alcohol consumption by the corresponding methylation-based measures