Table 4.

Odds ratios^a (pooled analysis) for subgroup analyses of the association between methylation-based measures of aging and lifestyle (regressed on their respective risk factors) and risk of breast cancer (N = 1,655)

	AA-Horvathb OR [95%CI]	AA-Hannumb OR [95%CI]	PhenoAgeb OR [95%CI]	GrimAgeb OR [95%CI]	Adj. BMI scorec OR [95%CI]	Adj. smoking scorec OR [95%CI]	Adj. alcohol scorec OR [95%CI]
Time to diagnosis
< 5 years	1.01 [0.88–1.16]	0.98 [0.84–1.13]	1.01 [0.88–1.17]	1.04 [0.92–1.19]	1.15 [1.01–1.32]	0.99 [0.87–1.13]	1.01 [0.88–1.15]
≥ 5 years	1.02 [0.94–1.11]	1.06 [0.97–1.16]	1.03 [0.95–1.13]	1.05 [0.96–1.14]	1.08 [1.00–1.17]	1.06 [0.98–1.14]	0.96 [0.88–1.05]
Age at blood draw
< 50	1.12 [0.92–1.36]	1.08 [0.89–1.32]	1.02 [0.84–1.23]	1.10 [0.93–1.30]	1.10 [0.93–1.30]	0.99 [0.85–1.14]	0.96 [0.81–1.14]
≥ 50	1.00 [0.92–1.09]	1.03 [0.94–1.12]	1.03 [0.95–1.12]	1.03 [0.95–1.11]	1.10 [1.02–1.19]	1.04 [0.96–1.13]	0.96 [0.89–1.05]
ER positivity status
ER positive	1.06 [0.98–1.16]	1.04 [0.95–1.14]	1.01 [0.93–1.10]	1.03 [0.95–1.12]	1.05 [0.97–1.14]	1.03 [0.95–1.12]	0.97 [0.89–1.06]
ER negative	0.87 [0.73–1.04]	0.93 [0.77–1.12]	1.02 [0.85–1.23]	1.18 [1.00–1.40]	1.15 [0.97–1.37]	1.05 [0.89–1.23]	0.92 [0.76–1.10]
Stage
I	1.05 [0.95–1.16]	1.04 [0.94–1.16]	1.02 [0.92–1.12]	1.07 [0.98–1.18]	1.09 [0.99–1.19]	1.03 [0.94–1.14]	0.96 [0.87–1.06]
II or higher	1.00 [0.88–1.15]	1.08 [0.93–1.25]	1.04 [0.91–1.20]	1.08 [0.94–1.24]	1.08 [0.95–1.23]	1.12 [0.98–1.28]	1.02 [0.89–1.17]

^aAdjusting for white blood cell proportions, except for AA-Horvath and AA-Hannum

^bRegressed on age

^cRegressed on log(BMI), log(pack-years) and log(alcohol in grams/day), respectively