Table 2.
Main results of the Mendelian randomization analysis
| Outcome | nSNPs | Method | OR (95% CI) | P value | PFDR |
|---|---|---|---|---|---|
| Neurodegenerative disease | |||||
| Alzheimer’s disease | 15 | IVW | 1.064 (1.012 to 1.119) | 0.014 | 0.056 |
| Parkinson’s disease | 17 | IVW | 1.027 (0.966 to 1.093) | 0.395 | 0.903 |
| Amyotrophic lateral sclerosis | 20 | IVW | 1.038 (0.996 to 1.080) | 0.075 | 0.240 |
| Multiple sclerosis | 11 | IVW | 1.008 (0.941 to 1.081) | 0.811 | 0.927 |
| Epilepsy | |||||
| Epilepsy | 7 | IVW | 1.044 (1.016 to 1.072) | 0.002 | 0.032 |
| Generalized epilepsy | 6 | IVW | 1.059 (1.011 to 1.109) | 0.013 | 0.069 |
| Focal epilepsy | 6 | IVW | 1.055 (1.015 to 1.097) | 0.007 | 0.056 |
| Cerebrovascular diseases | |||||
| Ischemic stroke | 17 | IVW | 1.012 (0.981 to 1.044) | 0.462 | 0.739 |
| Large-artery atherosclerosis | 17 | IVW | 1.011 (0.934 to 1.094) | 0.795 | 0.978 |
| Small-vessel | 16 | IVW | 0.978 (0.885 to 1.081) | 0.662 | 0.883 |
| Cardioembolic | 17 | IVW | 0.981 (0.915 to 1.051) | 0.587 | 0.854 |
| Nontraumatic intracranial hemorrhage | 13 | IVW | 1.064 (0.975 to 1.162) | 0.165 | 0.440 |
| Subarachnoid hemorrhage | 13 | IVW | 1.057 (0.931 to 1.200) | 0.396 | 0.792 |
| Migraine | |||||
| Migraine with aura | 17 | IVW | 1.006 (0.935 to 1.082) | 0.879 | 0.938 |
| Migraine without aura, drug-induced | 17 | IVW | 0.888 (0.650 to 1.213) | 0.454 | 0.807 |
| Migraine without aura and triptan purchases | 17 | IVW | 1.003 (0.928 to 1.084) | 0.936 | 0.936 |
Bold symbol indicated statistically significances (P < 0.05)
CI: confidence interval; FDR: false discovery rate; IVW: inverse-variance weighted; nSNPs: number of single-nucleotide polymorphisms; OR: odds ratio