Table 3.
Sensitivity analysis of the associations between plasma sTrem1 levels and neurological diseases
| Outcome | Weighted Median | MR-PRESSO | MR-Egger | Simple mode | Weighted mode |
|---|---|---|---|---|---|
| OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | |
| P value | P value | P value | P value | P value | |
| Neurodegenerative diseases | |||||
| Alzheimer’s disease | 1.089 (1.027, 1.154) | 1.064 (1.010, 1.212) | 1.085 (0.986, 1.194) | 1.039 (0.926, 1.166) | 1.084 (1.021, 1.152) |
| 0.004 | 0.033 | 0.120 | 0.526 | 0.020 | |
| Parkinson’s disease | 1.080 (1.006, 1.160) | 1.026 (0.967, 1.089) | 1.157 (1.046, 1.280) | 0.963 (0.764, 1.214) | 1.087 (1.012, 1.168) |
| 0.030 | 0.401 | 0.013 | 0.755 | 0.035 | |
| Amyotrophic lateral sclerosis | 1.037 (0.985, 1.092) | 1.034 (1.007, 1.062) | 1.055 (0.977, 1.139) | 0.998 (0.909, 1.095) | 1.035 (0.980, 1.092) |
| 0.167 | 0.021 | 0.189 | 0.961 | 0.235 | |
| Multiple sclerosis | 0.997 (0.934, 1.065) | 1.014 (0.953, 1.079) | 1.029 (0.903, 1.174) | 1.049 (0.902, 1.220) | 1.000 (0.934, 1.072) |
| 0.934 | 0.667 | 0.674 | 0.549 | 1.000 | |
| Epilepsy | |||||
| Epilepsy | 1.039 (1.008, 1.070) | 1.042 (1.019, 1.065) | 1.022 (0.971, 1.076) | 1.064 (0.997, 1.135) | 1.039 (1.008, 1.073) |
| 0.012 | 0.008 | 0.434 | 0.110 | 0.049 | |
| Generalized epilepsy | 1.060 (1.009, 1.114) | 1.059 (1.036, 1.083) | 1.072 (0.982, 1.170) | 1.059 (0.965, 1.161) | 1.060 (1.005, 1.117) |
| 0.020 | 0.002 | 0.196 | 0.281 | 0.084 | |
| Focal epilepsy | 1.052 (1.015, 1.092) | 1.050 (1.009, 1.092) | 1.001 (0.942, 1.063) | 1.133 (1.013, 1.267) | 1.041 (1.005, 1.077) |
| 0.006 | 0.049 | 0.984 | 0.080 | 0.074 | |
| Cerebrovascular diseases | |||||
| Ischemic stroke-all | 1.012 (0.973, 1.054) | 1.015 (0.985, 1.045) | 1.016 (0.958, 1.077) | 0.986 (0.906, 1.074) | 1.013 (0.973, 1.054) |
| 0.546 | 0.357 | 0.600 | 0.757 | 0.548 | |
| Large-artery atherosclerosis | 0.985 (0.893, 1.086) | 1.016 (0.951, 1.085) | 0.990 (0.855, 1.147) | 0.994 (0.821, 1.204) | 0.987 (0.889, 1.096) |
| 0.765 | 0.652 | 0.897 | 0.952 | 0.807 | |
| Small-vessel | 0.977 (0.891, 1.072) | 0.977 (0.888, 1.075) | 0.958 (0.789, 1.162) | 1.027 (0.848, 1.244) | 0.981 (0.891, 1.081) |
| 0.626 | 0.638 | 0.669 | 0.790 | 0.707 | |
| Cardioembolic | 0.986 (0.914, 1.064) | 0.990 (0.922, 1.062) | 1.005 (0.880, 1.147) | 0.995 (0.857, 1.154) | 0.987 (0.918, 1.062) |
| 0.721 | 0.781 | 0.947 | 0.943 | 0.738 | |
| Nontraumatic intracranial hemorrhage | 1.094 (0.978, 1.223) | 1.066 (0.984, 1.155) | 1.100 (0.939, 1.288) | 1.028 (0.840, 1.258) | 1.089 (0.973, 1.218) |
| 0.116 | 0.140 | 0.265 | 0.793 | 0.162 | |
| Subarachnoid hemorrhage | 1.036 (0.891, 1.203) | 1.080 (0.960, 1.211) | 1.041 (0.831, 1.306) | 0.960 (0.715, 1.288) | 1.036 (0.883, 1.216) |
| 0.648 | 0.225 | 0.732 | 0.790 | 0.671 | |
| Migraine | |||||
| Migraine with aura | 0.944 (0.858, 1.039) | 0.988 (0.911, 1.072) | 0.919 (0.806, 1.048) | 1.049 (0.841, 1.308) | 0.944 (0.854, 1.043) |
| 0.242 | 0.781 | 0.228 | 0.679 | 0.272 | |
| Migraine without aura, drug-induced | 0.793 (0.524, 1.199) | 0.893 (0.720, 1.108) | 0.756 (0.432, 1.322) | 1.467 (0.671, 3.206) | 0.772 (0.519, 1.150) |
| 0.272 | 0.320 | 0.342 | 0.351 | 0.221 | |
| Migraine without aura and triptan purchases | 0.978 (0.881, 1.085) | 0.999 (0.944, 1.058) | 1.020 (0.887, 1.173) | 0.980 (0.800, 1.200) | 0.973 (0.873, 1.086) |
| 0.671 | 0.985 | 0.783 | 0.847 | 0.636 |
Bold symbol indicated statistically significances (P < 0.05)
CI: confidence interval; MR-PRESSO: Pleiotropy Residual Sum and Outlier; OR: odds ratio; sTrem1: soluble triggering receptor expressed on myeloid cell 1