Table 1.
Demographic, imaging, and clinical characteristics of the study participants
| Overall | With SCD | Without SCD | |
|---|---|---|---|
| Variable | N = 250 | N = 70 | N = 180 |
| Age, years | 63.5 (4.8) | 63.9 (4.3) | 63.3 (4.9) |
| Female,n(%) | 153 (61.2) | 43 (61.4) | 110 (61.1) |
| Family history of sporadic AD,n(%)a | 197 (89.1) | 53 (75.7) | 144 (80) |
| Caucasian,n(%) | 248 (99.2) | 68 (97.1) | 180 (100) |
| Education, years | 13.3 (3.5) | 13.8 (3.4) | 13.1 (3.5) |
| Aβ-positive (≥ 12CL),n(%)b | 26 (12.7) | 7 (10) | 19 (10.6) |
| SCD-Q, MyCog scoresc | 4.1 (4.4) | 8.2 (4.5) | 2.5 (3.1) |
| Pre-confinement HADS total scores | 6.6 (4.8) | 8.3 (5.1) | 6 (4.5) |
| Confinement HADS total scores | 8.1 (5.9) | 9.4 (6.1) | 7.6 (5.7) |
| PSS scoresd | 16.1 (8.6) | 18 (9.1) | 15.4 (8.3) |
| BRS scorese | 3.2 (0.4) | 3.1 (0.3) | 3.2 (0.4) |
| Change in HADS from pre-confinement to confinement | 1.5 (5.8) | 1.1 (5.2) | 1.6 (5.9) |
| Currently diagnosed/under treatment for anxiety/depression,n(%)f | 26 (10.4) | 9 (12.9) | 17 (9.4) |
| Seeking medical help due to the self-perceived decline in cognition | 22 (8.8) | 22 (31.4) | – |
Data are presented as mean (standard deviation) unless otherwise indicated
Abbreviations: AD Alzheimer’s disease, SCD subjective cognitive decline, Aβ amyloid-beta, CL Centiloid, SCD-Q Subjective Cognitive Decline Questionnaire, HADS Hospital Anxiety and Depression Scale, PSS Perceived Stress Scale, BRS Brief Resilience Scale
aOverall N = 221
bOverall N = 205
cOverall N = 246
dOverall N = 238
eOverall N = 238
fOverall N = 248