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. 2022 Sep 5;20:403. doi: 10.1186/s12951-022-01609-0

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Effects of cells in TME on the progression and metastasis of sarcoma. The boxes represent the final effect on sarcoma after cellular interactions. Each red box and dotted arrow denote pro-tumor effects of microenvironment cells, and the double-head arrows indicate bidirectional actions. Green box and solid arrow represent anti-tumor effects of microenvironment cells