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. 2022 Sep 5;20:403. doi: 10.1186/s12951-022-01609-0

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — Exosomal lncRNA ANCR dictates in vitro sensitivity of sarcoma to doxycycline, expression of which is critical for drug resistance, tumor progression, and overall survival of patients. A Relative growth rate of the drug resistant cells mock-transfected, or transfected with non-silencing control siRNA, or siRNA targeting DANCR were quantified using CCK8 assay. b Cell viability of the differently transfected drug resistant cells after treated with doxycycline. c Representative IHC staining of osteocalcin. Nude mice were injected with sarcoma cells pre-treated with exosomes and added to sarcoma cells. All mice were treated with doxycycline orally once every 3 days for 4 weeks. Knockdown of DANCR made sarcoma cells sensitive to doxycycline and inhibited lung metastasis. d The tumor growth rate. e Expression of DANCR in OS patients sensitive or resistant to Adriamycin (n = 10 each) via using RT-qPCR. f Kaplan–Meyer survival curve showed significantly higher overall survival in patients with lower ANCR expression (median survival 4.56 years) than those with higher ANCR expression (median survival 2.26 years; P = 0.0071)

(Reprinted with permission from Ref [95] Copyright © 2022, Frontiers in oncology, Xin Hu et al.)