Table 1.

Gene regions and corresponding positions used for different drug targets

Exposure drug target	Gene	Gene position (GRCh37/hg19)	#SNPs (p < 5 × 10−8, r2 < 0.1)	R2	F-statistic
Beta1-adrenoceptor blockers	ADRB1	Chr10: 115,803,625–115,806,663	2	0.00028	105.49
Calcium channel blockers	CACNA1C	Chr3: 53,528,638–53,847,760	4	0.00029	55.09
	CACNA1D	ChrX: 49,061,523–49,089,802	0	-	-
	CACNA1F	Chr7: 81,575,760–82,073,272	0	-	-
	CACNA1S	Chr3: 50,400,044–50,541,675	0	-	-
	CACNA2D1	Chr1: 201,008,640–201,081,554	0	-	-
	CACNA2D2	Chr17: 37,329,706–37,353,922	0	-	-
	CACNB1	Chr10: 18,429,353–18,832,486	16	0.0015	72.81
	CACNB2	Chr12: 49,208,263–49,222,724	1	9.28e × 10−05	70.28
	CACNB3	Chr2: 152,689,285–152,955,681	0	-	-
	CACNB4	Chr17: 65,040,670–65,052,913	0	-	-
	CACNG1	Chr12: 2,162,153–2,807,116	2	0.0020	38.69

F-statistic for systolic blood pressure is 62.77. Gene position obtained using DBSNP. Reported windows do not include ± 10kB window. F-statistic calculated using the formula $F=\frac{(n-k-1)}{k}\frac{(R^2)}{(1-R^2)}$, where we calculated $R^2$ by summing SNP-wise $R^2$ (using the formula $R^2=\frac{F}{(N-2+F)}$, with $F={\left(\frac{\beta }{SE(\beta )}\right)}^2$) to find joint $R^2$

Abbreviations: chr chromosome, “-” not available