Figure 1.

CD47 binding partners and downstream signaling mediators of CD47-SIRPα interaction.The type of signals triggered by CD47 relies on many factors, of which the foremost is the type of ligand that it binds. Three major groups of ligands are identified to exhibit capacity of binding to CD47, namely, SIRPα, TSP-1, and integrins. The interaction between CD47 and SIRPα causes cytoplasmic ITIM phosphorylation and subsequently recruits SHP-1/2. Both of SHP-1 and SHP-2 can inhibit accumulation of myosin-IIA at the phagocytic synapse, which finally inhibit the process of phagocytosis.