Fig. 1.

Generation of Cancer-iPSCs: Cancer cells can be isolated from tumor bulk and differentiate into cancer-iPSCs by reprogramming pluripotent factors in vitro. These cells have immortality and proliferation capacity, and they can make tumors. They acquire pluripotency and teratoma formation character during reprogramming stages. Immortality, proliferation, pluripotency, and teratoma formation are four characteristics that can also be seen in CSCs