Table 1.

Logistic multivariate regression results

Variables	OR	SE	z	P-value	95% CI
Intercept	0.000	0.000	− 13.160	< 0.001*	(0.000, 0.000)
Statin groups
0. Low-dose hydrophilic	1.000	–	–	–	–
1. High-dose hydrophilic	0.811	0.565	− 0.300	0.763	(0.207, 3.177)
2. Low-dose lipophilic	0.743	0.306	− 0.720	0.470	(0.331, 1.664)
3. High-dose lipophilic	1.227	0.523	0.480	0.630	(0.533, 2.829)
Medications
Antifungals	2.865	2.095	1.440	0.150	(0.683, 12.008)
Clarithromycin	2.777	1.297	2.190	0.029*	(1.112, 6.934)
Ticagrelor	2.220	1.344	1.320	0.188	(0.678, 7.271)
Cyclosporine	2.127	1.306	1.230	0.219	(0.638, 7.089)
Carvedilol	1.534	0.442	1.490	0.138	(0.872, 2.697)
Colchicine	1.327	0.459	0.820	0.413	(0.674, 2.613)
Amiodarone	0.654	0.319	− 0.870	0.384	(0.251, 1.703)
Digoxin	0.594	0.441	− 0.700	0.483	(0.138, 2.549)
Diltiazem	0.865	0.451	− 0.280	0.781	(0.311, 2.405)
Ezetimibe	0.712	0.256	− 0.950	0.344	(0.352, 1.439)
Ciprofloxacin	0.419	0.196	− 1.860	0.063	(0.167, 1.049)
Gemfibrozil	0.508	0.513	− 0.670	0.503	(0.070, 3.674)
Other covariables
AST (> 30 U/L)	35.294	20.824	6.040	< 0.001*	(11.104, 112.181)
eGFR (< 60 mL/min/1.73 m2)	2.360	0.617	3.280	0.001*	(1.413, 3.940)
Hypertension	1.774	0.504	2.020	0.044*	(1.017, 3.095)
Age (> 65 years old)	0.640	0.157	− 1.820	0.069	(0.396, 1.036)
LDL (> 125 mg/dL)	0.409	0.122	− 3.010	0.003*	(0.228, 0.733)

Variables	Odds Ratio	Std. Err	z	P-value	95% CI
Interaction effects of high-dose lipophilic statin
+ Clarithromycin	5.662	4.908	2.000	0.046*	(1.035, 30.962)
+ Antifungals	5.840	6.071	1.700	0.090	(0.761, 44.796)
+ Clarithromycin  + Antifungals	16.219	18.309	2.470	0.014*	(1.775, 148.226)
+ Ticagrelor	4.526	4.256	1.610	0.108	(0.717, 28.584)
+ Cyclosporine	4.337	4.157	1.530	0.126	(0.662, 28.389)
+ Carvedilol	3.127	2.430	1.470	0.142	(0.681, 14.344)
+ Colchicine	2.705	2.180	1.230	0.217	(0.558, 13.125)

* p < 0.05