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Group comparisons of CSF C1q and C3b concentration. A C1q in clinical groups; B C1q in genetic subgroups; C C3b in clinical groups; D C3b in genetic subgroups. Orange circles indicate presymptomatic carriers who developed symptoms during follow-up, one of whom was excluded from C3b analyses due to a duplicate CV > 20%. P-values were derived from ANCOVAs on log-transformed biomarker data with age and sex as covariates. Pre presymptomatic, Sym symptomatic
