Table 2.

Plasma complement levels per clinical group

	Non-carriers	Presymptomatic carriers	Symptomatic carriers	p
C2	0.358 (0.274–0.532)	0.332 (0.274–0.431)	0.411 (0.319–0.548)	0.006*
C4b	9.97 (8.00–12.3)	9.92 (8.15–12.8)	10.8 (8.88–14.3)	0.913
C5	29.1 (21.6–35.8)	27.0 (21.7–35.2)	31.0 (25.1–38.3)	0.358
Factor D	3.57 (2.99–4.37)	3.46 (2.69–4.15)	4.19 (3.50–5.28)	0.481
MBL	2.44 (0.841–4.20)	2.01 (0.860–4.12)	1.71 (0.763–4.41)	0.710
Factor I	39.6 (32.9–46.6)	37.9 (32.8–45.2)	40.9 (35.0–47.0)	0.863
C1q	71.4 (64.5–81.2)	71.2 (60.6–80.1)	68.7 (62.2–76.2)	0.636
C3	44.8 (29.9–98.2)	39.9 (29.9–58.8)	45.5 (30.5–102)	0.047**
C4	293 (254–360)	297 (252–348)	294 (254–349)	0.577
Factor B	168 (147–211)	167 (146–205)	170 (143–202)	0.772
Factor H	250 (213–295)	250 (212–288)	254 (228–285)	0.849

All concentrations are expressed as medians (interquartile range) in µg/ml. P-values are derived from quantile regression models with age and sex as covariates. MBL mannose-binding lectin. *Pairwise comparisons: symptomatic vs presymptomatic carriers: p = 0.028. **Pairwise comparisons: symptomatic vs presymptomatic carriers: p = 0.004