Table 1.

Exosomal miRNAs in B-CLL

mRNAs	Expression in CLL	Target	Function	Oncogenic or Suppressive	Refs.
miR-202-3p	Upregulated	Sufu gene	‘suppressing fused’ (Sufu) is targeted by gene of miR-202-3p increase, modulator of the Gli Hedgehog signaling pathway -During development, it is thought to be involved in pattern formation and cellular proliferation. - decreasing in the intracellular level of this miRNA causes an increase in the expression level of Sufu, which aids tumor cell survival and progression.	Oncogene	[69, 71]
miR-146a/miR-451	Upregulated	Kinases in Stromal cells	inducing the stromal cells activation by phosphorylation of several kinases	Oncogene	[69, 71, 75]
miR-150	Upregulated	c-Myb	playing an important role in the process of hematopoiesis, particularly in the development of lymphoid lineage	Oncogene	[69, 71]
miR-19b	Upregulated	TP53 and MKI67	TP53 downregulation and MKI67 upregulation as tumor cell proliferation, survival, and invasion mechanisms	Oncogene	[69, 76]
miR-155	Upregulated	SHIP1	In CLL, it has an oncogenic role; it promotes the BCR response by targeting SHIP1.	Oncogene	[69, 71]
miR-29	Downregulated	TCL1	regulation of TCL1, MCL1 and DNA-methyltransferases	Tumor suppressor function in aggressive CLLs (downregulated versus indolent CLL)	[69, 71]
miR-223	Downregulated	HSPs	HSP90B1	Oncogene	[69, 77, 78]
Y RNA	Upregulated		it is overexpressed in tumors and is essential for cell proliferation	Oncogene	[69, 79]