Table 2.

Exosomal miRNAs associating in CML and AML

miRNA	Malignancy	Alteration mode	Function/description	Refs.
Pre-miR-92a	CML	Increased	Down-regulating the integrin a5 and improving endothelial the cell movement and tube formation.	[100]
miR-210	CML	Increased	Interacting with Ephrin-A3 and playing a vital role in angiogenesis and VEGF signaling.	[101]
miR365	CML	Increased	Drug resistance by preventing the production of pro-apoptosis proteins.	[105]
miR-150, miR-155 and miR-1246	AML	Increased	Their high serum levels lead to considering them as minimally-invasive early biomarker of AML. promoting the apoptosis and differentiation of LSCs through inactivation of STAT3 pathway.	[109]
miR-425-5p	AML	Decreased	Inhibiting cell viability, invasion and migration via inducing apoptosis genes of AML cells such as cleaved PARP, cleaved caspase3 and Wilms tumor 1-associated protein (WTAP).	[110]
miR-21 and miR-29	AML	Increased	Promoting the survival of healthy hematopoietic stem cells and inducing leukemia-like functional features in them	[112, 113]