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. Author manuscript; available in PMC: 2022 Sep 6.
Published in final edited form as: Nat Cell Biol. 2021 Mar 8;23(3):232–242. doi: 10.1038/s41556-021-00644-7

Fig. 6 |. High MYOF expression levels correlate with aggressive disease.

Fig. 6 |

a. MYOF transcript levels in human PDA specimens and normal pancreas (adjacent non-neoplastic tissue) from the indicated datasets. The number of samples are indicated under each graph in parentheses. b. Immuno-histochemistry showing increased expression of MYOF in primary patient PDA tumour epithelia (arrowheads) compared to normal pancreas or adjacent stroma (asterisk). Scale, 100μm. c. Percentage distribution of semi-quantitative histoscore of MYOF staining across normal adjacent (n = 102 patient samples) and primary PDA (n = 136 patient samples). d, e. High expression of MYOF predicts shorter overall survival in two patient cohorts. N = 136 patients in the UCLA cohort (MYOF high n=31, MYOF low n=105) and n = 185 in The Cancer Genome Atlas (TCGA) cohort (MYOF high; Z score > 1, n = 27 pateint samples; MYOF low Z score < 1, n = 158 patient samples). p-Value calculated by Log-rank test. f. Model comparing lysosomal response to stress in normal (left) and PDA (right) cells. Lysosomal retargeting of MYOF in PDA cells provides protection against membrane stress caused by increased rates of vesicular traffic. Loss of MYOF renders PDA lysosomes more vulnerable to damage. Data are mean ± s.d. P values determined by unpaired two-tailed t-tests. Statistics source data are provided in Source data.