Figure 4.

Miz1 in dendritic or myeloid cells contributes to OVA-induced asthma. Control Miz1(POZ)^fl/fl, CD11c-Cre/Miz1(POZ)^fl/fl, or LysM-Cre/Miz1(POZ)^fl/fl mice were subjected to OVA/alum-induced allergic asthma. (A) Production of the Th2 cytokines in the BAL fluid of OVA-treated mice as indicated. n = 5 with technical replicates. (B) mRNA concentrations of the Th2 cytokines in whole-lung homogenates of OVA-treated mice as indicated. n = 5 with technical replicates. (C) Lung histology by hematoxylin and eosin staining in the airways of OVA-treated mice as indicated. Values represent the mean ± SEM. Unpaired Student's t test was used. *P < 0.05, **P < 0.01, and ***P < 0.001.