Figure 4.

TLR7 deficiency attenuates lung injury in murine sepsis. Twenty-four hours after sham or CLP procedure, BAL, plasma, and lung were collected from both WT and TLR7^−/− mice. (A) IL-6 and CXCL2 in the BAL. (B) IL-6 and ICAM-1 gene expression in the lung tissue. (C) Alveolar–capillary permeability was measured by leakage of fluorescein isothiocyanate (FITC)–dextran (40 kD) from blood circulation to alveolar space presented as the ratio of FITC fluorescence in BAL to plasma. n = 4–6/group. Data were presented as mean ± SEM and analyzed by two-way ANOVA with Bonferroni’s post hoc test.