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Proposed relationship between lung infection and neurovascular dysfunction. Infection causes the production of cytotoxic tau variants in lung capillary endothelium that disseminate through the circulation and access the brain, where they disrupt hippocampal neuronal information processing. Heparan sulfate from lung matrix degradation and β amyloid also increase in the circulation and interfere with neural information processing. It was modified with permission from reference 225.
