Table 2.
Annual Average Age-Specific Incidence Ratesa for Brain and Other Central Nervous System Tumors Ages 0–19 Years by Major Histopathology Groupings, Histopathology, and Sex, CBTRUS Childhood and Adolescent Brain Tumor Report: NPCR and SEER, 2014–2018
| Histopathology | Total | Male | Female | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Total Cases (2014–2018) | Annual Average | Median Age | % All tumors | Rate (95% CI) | Total Cases (2014–2018) | Annual Average | Rate (95% CI) | Total Cases (2014–2018) | Annual Average | Rate (95% CI) | |
| Gliomasb | 11,474 | 2,295 | 8 | 45.0 | 2.80 (2.75–2.85) | 6,041 | 1,208 | 2.89 (2.82–2.96) | 5,433 | 1,087 | 2.71 (2.64–2.79) |
| Pilocytic astrocytoma | 3,877 | 775 | 7 | 15.2 | 0.95 (0.92–0.98) | 1,983 | 397 | 0.95 (0.91–0.99) | 1,894 | 379 | 0.95 (0.90–0.99) |
| Other Low grade glioma | 2,164 | 433 | 11 | 8.5 | 0.53 (0.51–0.55) | 1,188 | 238 | 0.57 (0.54–0.60) | 976 | 195 | 0.49 (0.46–0.52) |
| High grade glioma | 2,361 | 472 | 9 | 9.3 | 0.58 (0.55–0.60) | 1,214 | 243 | 0.58 (0.55–0.61) | 1,147 | 229 | 0.57 (0.54–0.61) |
| Other glioma | 6,949 | 1,390 | 7 | 27.3 | 1.70 (1.66–1.74) | 3,639 | 728 | 1.74 (1.68–1.80) | 3,310 | 662 | 1.65 (1.60–1.71) |
| Ependymal tumors | 1,176 | 235 | 7 | 4.6 | 0.29 (0.27–0.30) | 664 | 133 | 0.32 (0.29–0.34) | 512 | 102 | 0.26 (0.23–0.28) |
| Choroid plexus tumors | 416 | 83 | 2 | 1.6 | 0.10 (0.09–0.11) | 238 | 48 | 0.11 (0.10–0.13) | 178 | 36 | 0.09 (0.08–0.10) |
| Neuronal and mixed neuronal-glial tumors | 1,282 | 256 | 12 | 5.0 | 0.31 (0.30–0.33) | 697 | 139 | 0.33 (0.31–0.36) | 585 | 117 | 0.29 (0.27–0.32) |
| Tumors of the pineal region | 213 | 43 | 9 | 0.8 | 0.05 (0.05–0.06) | 107 | 21 | 0.05 (0.04–0.06) | 106 | 21 | 0.05 (0.04–0.06) |
| Embryonal tumors | 2,397 | 479 | 5 | 9.4 | 0.59 (0.56–0.61) | 1,431 | 286 | 0.68 (0.65–0.72) | 966 | 193 | 0.48 (0.45–0.51) |
| Medulloblastoma | 1,662 | 332 | 7 | 6.5 | 0.41 (0.39–0.43) | 1,063 | 213 | 0.51 (0.48–0.54) | 599 | 120 | 0.30 (0.28–0.32) |
| ATRT | 383 | 77 | 1 | 1.5 | 0.09 (0.08–0.10) | 191 | 38 | 0.09 (0.08–0.11) | 192 | 38 | 0.10 (0.08–0.11) |
| Other embryonal tumors | 352 | 70 | 3 | 1.4 | 0.09 (0.08–0.10) | 177 | 35 | 0.08 (0.07–0.10) | 175 | 35 | 0.09 (0.07–0.10) |
| Tumors of cranial and spinal nerves | 1,202 | 240 | 12 | 4.7 | 0.29 (0.28–0.31) | 651 | 130 | 0.31 (0.29–0.34) | 551 | 110 | 0.28 (0.25–0.30) |
| Tumors of meninges | 1,291 | 258 | 14 | 5.1 | 0.32 (0.30–0.33) | 622 | 124 | 0.30 (0.27–0.32) | 669 | 134 | 0.33 (0.31–0.36) |
| Lymphomas and hematopoietic neoplasms | 135 | 27 | 11 | 0.5 | 0.03 (0.03–0.04) | 78 | 16 | 0.04 (0.03–0.05) | 57 | 11 | 0.03 (0.02–0.04) |
| Germ cell tumors | 849 | 170 | 12 | 3.3 | 0.21 (0.19–0.22) | 596 | 119 | 0.28 (0.26–0.31) | 253 | 51 | 0.13 (0.11–0.14) |
| Tumors of sellar region | 4,484 | 897 | 16 | 17.6 | 1.10 (1.06–1.13) | 1,420 | 284 | 0.68 (0.64–0.72) | 3,064 | 613 | 1.53 (1.48–1.58) |
| Tumors of the pituitary | 3,639 | 728 | 16 | 14.3 | 0.89 (0.86–0.92) | 946 | 189 | 0.45 (0.42–0.48) | 2,693 | 539 | 1.34 (1.29–1.40) |
| Craniopharyngioma | 845 | 169 | 9 | 3.3 | 0.21 (0.19–0.22) | 474 | 95 | 0.23 (0.21–0.25) | 371 | 74 | 0.19 (0.17–0.21) |
| Unclassified Tumors | 1,570 | 314 | 11 | 6.2 | 0.38 (0.36–0.40) | 808 | 162 | 0.39 (0.36–0.41) | 762 | 152 | 0.38 (0.35–0.41) |
| Totalc | 25,497 | 5,099 | 9 | 100.0 | 6.23 (6.15–6.30) | 12,780 | 2,556 | 6.11 (6.00–6.22) | 12,717 | 2,543 | 6.35 (6.24–6.46) |
aRates are per 100,000.
bCBTRUS defines the broad category of gliomas to include ICD-O-3 histopathology codes 9380–9384, 9391–9460, 9480.
cIncludes histopathologies not listed in this table.
Abbreviations: CBTRUS, Central Brain Tumor Registry of the United States; NPCR, National Program of Cancer Registries; SEER, Surveillance, Epidemiology and End Results Program; CI, confidence interval; NOS, not otherwise specified; ATRT, Atypical teratoid/rhabdoid tumor.