Table 1. Metabolic hits with prognostic capacity.
Hits displayed with respective relapse-free survival (RFS) and distant metastasis-free survival (DMFS) P-values.
| Pathway | Target | Log-Rank p-value* | |
|---|---|---|---|
| RFS | DMFS | ||
| Anaplerosis/TCA | GOT1 | 1.00E-16 | 1.30E-10 |
| SLC1A3 | 5.50E-06 | 2.80E-05 | |
| PDHA1 | 3.70E-04 | 1.80E-04 | |
| Creatine | SLC6A8 | 9.70E-15 | 2.10E-05 |
| GATM | 1.40E-16 | 2.30E-15 | |
| Glycolysis | MCT4 | 1.00E-16 | 8.80E-15 |
| MCT3 | 1.00E-16 | 8.80E-14 | |
| GLUT1 | 1.10E-06 | 3.40E-10 | |
| HK2 | 3.70E-11 | 7.80E-07 | |
| LDHA | 1.00E-16 | 1.30E-03 | |
| MCT1 | 8.30E-07 | 3.20E-03 | |
| Glycosylation | PGM1 | 4.50E-07 | 5.80E-06 |
| UGT | 2.90E-12 | 8.00E-06 | |
| UGGT1 | 4.60E-08 | 4.60E-05 | |
| Kynurenine/NAD+ | QPRT | 7.40E-09 | 7.40E-09 |
| TDO | 3.50E-05 | 3.10E-08 | |
| KYNU | 5.10E-10 | 3.20E-04 | |
| KMO | 1.00E-04 | 1.00E-03 | |
| NAD+ salvage pathway | NAMPT | 2.60E-03 | 6.60E-03 |
| NAPRT | 7.80E-03 | 1.40E-02 | |