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. 2022 Sep 6;17(9):e0271689. doi: 10.1371/journal.pone.0271689

Fig 4. Abatacept enhances the levels of conventional Tregs (cTregs) in lung tissues and peripheral blood of OVA- sensitized mice.

Fig 4

(A) Percentage of cTregs (Foxp3+ cells within CD4+CD25+) in the lung tissues of abatacept IN, abatacept IP treated, or OVA challenged mice. (B) Percentage of LAG3+ cTregs (CD25+Foxp3+LAG3+) in the lung tissues of abatacept IN, abatacept IP treated, or OVA challenged mice. (C) Percentage of cTregs in the PBMCs of abatacept IN, abatacept IP treated, or OVA challenged mice. (D) Percentage of LAG3+ cTregs in the lung tissues of abatacept IN, abatacept IP treated, or OVA challenged mice. Lung tissues of 5 mice and PBMCs of 10 mice were used. Two-way unpaired t-test was used to calculate significance. * ***P < 0.001. Events were recorded and analysed by using BD FACSDiva version 8.0.