1	exp Mastectomy, Subcutaneous/ or exp Mastectomy, Extended Radical/ or exp Mastectomy, Segmental/ or exp Mastectomy/ or exp Mastectomy, Radical/ or exp Mastectomy, Modified Radical/ or exp Mastectomy, Simple/
2	mastectom$.tw.
3	(simple mastectom$ or total mastectom$).tw.
4	(skin‐sparing mastectom$ or skin sparing mastectom$).tw.
5	(nipple‐sparing mastectom$ or nipple sparing mastectom$).tw.
6	(segmental mastectom$ or partial mastectom$).tw.
7	(radical mastectom$ or modified radical mastectom$ or extended radical mastectom$).tw.
8	subcutaneous mastectom$.tw.
9	exp Mammaplasty/
10	mamm?plast$.tw.
11	or/1‐10
12	prophylac$.tw.
13	prophylaxis.tw.
14	prevent$.tw.
15	(risk‐reducing or RRM).tw.
16	or/12‐15
17	11 and 16
18	(prophylactic$ adj (surger$ or resect$ or mastectom$ or mamm?plast$)).tw.
19	(prevent$ adj (surger$ or resect$ or mastectom$ or mamm?plast$)).tw.
20	(risk‐reducing adj (surger$ or resect$ or mastectom$ or mamm?plast$)).tw.
21	exp Prophylactic Mastectomy/
22	exp Prophylactic Surgical Procedures/
23	or/18‐22
24	17 or 23
25	exp Risk Assessment/
26	exp Risk Factors/
27	exp Medical History Taking/
28	Family history.tw.
29	(lifetime risk adj6 breast cancer).tw.
30	history of breast cancer.tw.
31	(famil* adj6 risk).tw.
32	(famil* adj6 history).tw.
33	(famil* adj6 breast).tw.
34	(famil* adj6 breast cancer).tw.
35	exp FAMILY/
36	family.tw.
37	exp RISK/
38	risk.tw.
39	(35 or 36) and (37 or 38)
40	or/25‐34,39
41	exp Genes, BRCA1/
42	exp Genes, BRCA2/
43	(BRCA1 or BRCA2).tw.
44	exp Genetic Predisposition to Disease/
45	genetic risk.tw.
46	exp Germ‐Line Mutation/
47	exp Li‐Fraumeni syndrome/
48	(Li‐Fraumeni syndrome or Li Fraumeni syndrome).tw.
49	exp BRCA1 Protein/
50	exp BRCA2 Protein/
51	(PALB2 adj mutation).tw.
52	((Partner and Localizer of BRCA2 gene) adj mutation).tw.
53	BRCA1 Protein.tw.
54	BRCA2 Protein.tw.
55	exp mutation/
56	or/41‐54
57	24 and (40 or 56)
58	animals/ not humans/
59	57 not 58
60	remove duplicates from 59