1	exp partial mastectomy/ or exp subcutaneous mastectomy/ or exp mastectomy/ or exp segmental mastectomy/ or exp simple mastectomy/ or exp radical mastectomy/ or exp modified radical mastectomy/ or exp extended radical mastectomy/ or exp skin‐sparing mastectomy/ or exp nipple‐sparing mastectomy/
2	mastectom$.tw.
3	(simple mastectom$ or total mastectom$).tw.
4	(skin‐sparing mastectom$ or skin sparing mastectom$).tw.
5	(nipple‐sparing mastectom$ or nipple sparing mastectom$).tw.
6	(segmental mastectom$ or partial mastectom$).tw.
7	(radical mastectom$ or modified radical mastectom$ or extended radical mastectom$).tw.
8	subcutaneous mastectom$.tw.
9	exp breast reconstruction/
10	mamm?plast$.tw.
11	or/1‐10
12	prophylac$.tw.
13	prophylaxis.tw.
14	prevent$.tw.
15	exp risk reduction/
16	(risk‐reducing or RRM).tw.
17	or/12‐16
18	11 nd 17
19	(prophylactic$ adj (surger$ or resect$ or mastectom$ or mamm?plast$)).tw.
20	(prevent$ adj (surger$ or resect$ or mastectom$ or mamm?plast$)).tw.
21	(risk‐reducing adj (surger$ or resect$ or mastectom$ or mamm?plast$)).tw.
22	exp prophylactic mastectomy/
23	exp prophylactic surgical procedure/
24	or/19‐23
25	18 or 24
26	exp risk assessment/
27	exp risk factor/
28	exp family history/
29	Family history.tw.
30	exp cancer risk/
31	(lifetime risk adj6 breast cancer).tw.
32	history of breast cancer.tw.
33	(famil* adj6 risk).tw.
34	(famil* adj6 history).tw.
35	(famil* adj6 breast).tw.
36	(famil* adj6 breast cancer).tw.
37	exp FAMILY/
38	family.tw.
39	exp RISK/
40	risk.tw.
41	(37 or 38) and (39 or 40)
42	or/26‐36,41
43	exp BRCA1 protein/
44	exp BRCA2 protein/
45	(BRCA1 or BRCA2).tw.
46	exp genetic predisposition/
47	exp genetic risk/
48	genetic risk.tw.
49	exp germline mutation/
50	exp Li‐Fraumeni syndrome/
51	(Li‐Fraumeni syndrome or Li Fraumeni syndrome).tw.
52	(PALB2 adj mutation).tw.
53	((Partner and Localizer of BRCA2 gene) adj mutation).tw.
54	BRCA1 Protein.tw.
55	BRCA2 Protein.tw.
56	exp mutation/
57	or/43‐56
58	25 and (42 or 57)
59	animals/ not humans/
60	58 not 59
61	remove duplicates from 60