Table 4.
Laboratory findings in patients with malaria
| Laboratory parameter | Severe P. falciparum malaria | Non-complicated P. falciparum malaria | Non-falciparum malaria | P value | |||
|---|---|---|---|---|---|---|---|
| Median | IQR | Median | IQR | Median | IQR | ||
| WBC (× 109/l) | 6.0 | 4.7–7.9 | 5.0 | 3.9–6.4 | 4.9 | 3.7–6.3 | 0.011 |
| ANC (× 109/l) | 4.6 | 3.6–6.8 | 3.6 | 2.6–4.7 | 2.7 | 1.9–4.1 | < 0.001 |
| ALC (× 109/l) | 0.8 | 0.4–1.0 | 0.7 | 0.4–1.1 | 0.8 | 0.6–1.5 | 0.047 |
| AMC (× 109/l) | 0.4 | 0.2–0.6 | 0.4 | 0.3–0.7 | 0.6 | 0.4–0.9 | 0.002 |
| Hb (g/l) | 138 | 119–149 | 146 | 132–155 | 139 | 121–145 | 0.002 |
| HCT (1/1) | 0.389 | 0.329–0.426 | 0.418 | 0.385–0.448 | 0.391 | 0.361–0.419 | < 0.001 |
| PLT (× 109/l) | 32 | 17–70 | 98 | 60–145 | 95 | 68–131 | < 0.001 |
| CRP (mg/l) | 167.4 | 135.5–246.9 | 76.2 | 31.7–139.7 | 74.6 | 44.1–148.1 | < 0.001 |
| Glycemia | 6.4 | 5.2–7.5 | 6.0 | 5.3–6.9 | 5.7 | 5.1–6.2 | 0.167 |
| Na (mmol/l) | 133 | 129–136 | 135 | 133–138 | 137 | 135–139 | < 0.001 |
| K (mmol/l) | 3.9 | 3.6–4.3 | 3.8 | 3.6–4.0 | 3.9 | 3.7–4.2 | 0.239 |
| Cl (mmol/l) | 99 | 97–104 | 100 | 98–103 | 103 | 100–105 | 0.018 |
| BUN (mmol/l) | 8.9 | 5.4–13.4 | 5.6 | 4.1–6.5 | 4.7 | 3.6–6.0 | < 0.001 |
| Cr (μmol/l) | 111 | 90–161 | 99 | 82–112 | 90 | 82–106 | 0.005 |
| Bilirubin (mmol/l) | 51 | 33–106 | 23 | 17–35 | 23 | 17–29 | < 0.001 |
| AST (μkat/l) | 1.27 | 0.88–2.26 | 0.70 | 0.52–1.05 | 0.54 | 0.39–0.86 | < 0.001 |
| ALT (μkat/l) | 0.93 | 0.67–1.43 | 0.66 | 0.45–1.23 | 0.65 | 0.40–1.08 | 0.063 |
| ALP (μkat/l) | 1.41 | 1.12–1.74 | 1.24 | 0.97–1.60 | 1.20 | 1.04–1.66 | 0.231 |
| GGT (μkat/l) | 1.21 | 0.55–1.70 | 0.86 | 0.42–1.71 | 0.63 | 0.33–2.11 | 0.466 |
| INR | 1.18 | 1.13–1.35 | 1.13 | 1.05–1.22 | 1.11 | 1.06–1.23 | 0.042 |
| APTT | 1.29 | 1.13–1.38 | 1.10 | 1.00–1.23 | 1.22 | 1.06–1.32 | 0.002 |
WBC white blood cell count, ANC absolute neutrophil count, ALC absolute lymphocyte count, AMC absolute monocyte count, Hb haemoglobin, HCT haematocrit, PLT platelet count, CRP C-reactive protein, BUN blood urea nitrogen, Cr creatinine, AST aspartate aminotransferase, ALT alanine aminotransferase, ALP alkaline phosphatase, GGT gamma-glutamyl transferase, INR international normalized ratio, APTT activated partial thromboplastin time ratio