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. 2022 Sep 5;37(6):e370605. doi: 10.1590/acb370605

Figure 5. CBL regulates neuroinflammation and apoptosis by modulating the TLR signaling pathway after TBI. (a) The levels of ROS by the DCF-DA method. (b) The expression of TLR2 and TLR4 in the brain cortex of mice after TBI was determined by Western blotting. (c-d) Quantification of TLR2 and TLR4 in the brain cortex compared to the β-actin loading control. CBL significantly decreased brain cortex TLR2 and TLR4 expression after TBI (n = 6, p < 0.05; analysis of variance; mean ± SEM).

Figure 5

CBL: cerebrolysin; TLR: toll-like receptor; TBI: traumatic brain injury; ROS: reactive oxygen species;DCF-DA: diacetylated 2’,7’-dichlorofluorescein; SEM: stardard error of mean.