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. 2022 Jul 21;133(3):637–646. doi: 10.1152/japplphysiol.00083.2022

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Figure 1. — Satellite cell depletion does not affect myonuclear number in young and old diaphragm with or without hypoxia. Representative images of vehicle-treated (A) and tamoxifen-treated (B) Pax7-DTA mouse diaphragm; scale bars represent 25 µm. Pax7⁺ cell count in vehicle- and tamoxifen-treated adult (C) and aged (D) diaphragm in normoxia and hypoxia. Myonuclei/100 µm in adult (E) and aged (F) diaphragm. *Main effect for tamoxifen treatment (P < 0.0001), #main effect for age (P < 0.0001). C and D: adult normoxia veh group n = 9, adult normoxia tam group n = 5, adult hypoxia veh group n = 8, adult hypoxia tam group n = 8, aged normoxia veh group n = 7, aged normoxia tam group n = 7, aged hypoxia veh group n = 7, aged hypoxia tam group n = 10. E and F: adult normoxia veh group n = 7, adult normoxia tam group n = 5, adult hypoxia veh group n = 9, adult hypoxia tam group n = 8, aged normoxia veh group n = 6, aged normoxia tam group n = 8, aged hypoxia veh group n = 8, aged hypoxia tam group n = 11. Differences in Pax7⁺ cell density and myonuclear cell density were tested using two-way ANOVA with Šídák’s multiple comparison correction. Age effects were detected using three-way ANOVA. Error bars represent SE. tam, tamoxifen; veh, vehicle.