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. 2022 Jul 21;133(3):637–646. doi: 10.1152/japplphysiol.00083.2022

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Figure 5. — Pax3 mRNA expression in diaphragm is higher with tamoxifen treatment and lower with age. Representative images of vehicle-treated (A) and tamoxifen-treated (B) Pax7-DTA mouse diaphragm; scale bars represent 25 µm. Pax3 mRNA⁺ cell count in vehicle- and tamoxifen-treated adult (C) and aged (D) diaphragm in normoxia and hypoxia. *Main effect for tamoxifen treatment (P < 0.0001); #main effect for age (P = 0.0002). Adult normoxia veh group n = 8, adult normoxia tam group n = 4, adult hypoxia veh group n = 6, adult hypoxia tam group n = 6, aged normoxia veh group n = 4, aged normoxia tam group n = 4, aged hypoxia veh group n = 4, aged hypoxia tam group n = 4. Differences in Pax3⁺ cell density was tested using two-way ANOVA with Šídák’s multiple comparison correction. Age effects were detected using three-way ANOVA. Error bars represent SE. tam, tamoxifen; veh, vehicle.