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ST266 alters the transcriptomic profile of the intestine in mice with NEC. Volcano plots showing the differentially expressed genes in the intestinal epithelium in NEC mice and breastfed controls (A), NEC mice and NEC mice administered ST266 orally (B), and NEC mice and NEC mice administered ST266 via intraperitoneal route (C). Vertical lines are drawn at a log2-fold change of 0.25. Expression values were z-score scaled. Adjusted P < 0.05, log2FC > 1. NEC, necrotizing enterocolitis.
