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. 2022 Aug 30;50(4):128. doi: 10.3892/ijmm.2022.5184

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Copyright: © Huang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Cell cycle non-specific mechanisms for the resistance to CDK4/6 inhibitors. FGF2, fibroblast growth factor 2; FGFR1, fibroblast growth factor receptor 1; ER, estrogen receptor; AR, androgen receptor; PDK1, 3-phosphoinositide-dependent protein kinase-1; DHT, 5-α-dihydrotestosterone; AP-1, activator protein 1; EMT, epithelial-mesenchymal transition; RB, retinoblastoma protein; P, phosphate; FAT1, FAT atypical cadherin 1; YAP, yes-associated protein; PIP, prolactin-induced protein; Smad, drosophila mothers against decapentaplegic protein.