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. 2022 Aug 17;11:e78811. doi: 10.7554/eLife.78811

Figure 1. Active periods and local field potential (LFP) properties of the mouse medial prefrontal cortex (mPFC) across the first 2 postnatal weeks.

(A) Schematic representation (Claudi et al., 2021) of extracellular recordings in the mPFC of P2-12 mice (left), and representative LFP traces from P3, P6, P9, and P12 mice (right). (B and C) Violin plots displaying the percentage of time spent in active periods (B) and the single unit activity (SUA) firing rate (C) of P2-12 mice (n=117 mice and 2269 single units, respectively). (D) Log-log plot displaying the normalized median power spectral density (PSD) power in the 1–40 Hz frequency range of P2-12 mice (n=117 mice). Color codes for age with 1 day increment. (E) Violin plot displaying the 1/f exponent of P2-12 mice (n=117 mice). In (B) and (E) white dots indicate individual data points. In (C) data are presented as median, 25th, 75th percentile, and interquartile range. In (B), (C), and (E) the shaded area represents the probability distribution density of the variable. In (D) data are presented as median. Asterisks in (B), (C), and (E) indicate significant effect of age. ***p<0.001. Generalized linear models (B–C) and linear model (E). For detailed statistical results, see Supplementary file 1.

Figure 1.

Figure 1—figure supplement 1. Local field potential (LFP) and single unit activity (SUA) properties of the mouse medial prefrontal cortex (mPFC) across the first 2 postnatal weeks.

Figure 1—figure supplement 1.

(A and B) Violin plots displaying the number (A) and duration (B) of active periods of P2-12 mice (n=117 mice). (C) Scatter plot displaying the time spent in active periods with respect to the number of active periods per minute of P2-12 mice (n=117 mice). Color codes for age. (D and E) Violin plot displaying the maximum amplitude of active periods (D) and the LFP power in the 1–40 Hz frequency range (E) of P2-12 mice (n=117 mice). (F) Log-log line plot displaying the median LFP power in the 0.1–4 Hz frequency range of P2-12 mice (n=117 mice). Color codes for age. In (A), (B), (D), and (E) white dots indicate individual data points and the shaded area represents the probability distribution density of the variable. In (F) data are presented as median. Asterisks in (B), (D), and (E) indicate significant effect of age. ***p<0.001. Generalized linear models. For detailed statistical results, see Supplementary file 1.