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Immunomodulatory roles of intracellular PG. Serglycin (SRGN) can modulate the activation status of the complement system. SRGN-CD44 interaction activates intracellular signaling pathways, such as NF-κB, promoting tumor aggressiveness. SRGN regulates IL-8 and TGF-β secretion, thus controlling crucial inflammatory networks in the TME. PG, proteoglycan. Created with BioRender.com.
