Figure 4.
Immunomodulatory roles of small leucine-rich PG (SLRPGs). Soluble biglycan and decorin bind TLR-2 and -4, resulting in production of various cytokines and chemokines, such as proinflammatory TNF-α and IL-1β, as well as anti-inflammatory IL-10. Decorin sequesters TGF-β and reduces the availability of miR-21, which results in decrease in IL-10 secretion. Biglycan can cluster TLR2/4 and purinergic receptors, P2X4/P2X7. APC, antigen-presenting cell; PG, proteoglycan. Created with BioRender.com.