Table 9.

ADMET profile of the M. champaca phytoconstituents and standard drugs.

Compounds	Drug-likeness parameters						Toxicological parameters
	cLogP	Mol. weight (g/mol)	HBA	HBD	nRB	Drug- score	Mutagenicity	Tumorigenicity	Irritability	Reproductive effectivity
1-Octen-3-yl glucoside	0.66	290.35	6	4	8	0.23	No risk	High risk	Medium risk	No risk
1-Phosphatidyl-1D-myoinositol 3-phosphate	–9.13	470.21	16	9	10	0.40	No risk	No risk	No risk	No risk
5′-Butyrylphosphoinosine	–3.28	418.30	13	4	8	0.43	No risk	No risk	No risk	No risk
Dihydrodeoxystreptomycin	–7.65	583.59	19	13	9	0.62	No risk	No risk	No risk	No risk
Doripenem	–3.68	420.51	10	5	6	0.86	No risk	No risk	No risk	No risk
Forsythiaside	–0.38	624.59	15	9	11	0.34	No risk	No risk	No risk	No risk
Isorhamnetin 3-O-[b-d-glucopyranosyl-(1-2)-a-l-rhamnopyranoside]	–0.98	624.55	16	9	7	0.32	No risk	No risk	No risk	No risk
Poncirin	–0.47	594.56	14	7	7	0.43	No risk	No risk	No risk	No risk
Salviaflaside methyl ester	–0.11	536.48	13	7	11	0.35	No risk	No risk	No risk	No risk
Diazepam	2.98	–4.67	3	0	1	0.20	High risk	High risk	No risk	High risk
Imipramine	3.89	280.41	2	0	4	0.51	No risk	No risk	No risk	High risk

cLogP: logarithm of its partition coefficient between n-octanol and water log(c_octanol/c_water); HBA: hydrogen bond acceptors; HBD: hydrogen bond donors; nRB: number of rotatable bonds.

Bold values indicate the result of selected compounds which were taken for ADMET studies.