Figure 3.

Decision-making group effect for the bilateral amygdala region of interest. Bar graphs depict percent signal change estimated marginal means (error bars depict ± 1 standard error) for a significant group effect for the bilateral amygdala in the decisionmaking phase (p = 0.023; d = −0.32); *p < 0.05. Compared to healthy participants, participants with anxiety or depression showed blunted activation of the amygdala during decision-making, regardless of the presence of conflict. We observed no significant group × trial type interaction. This amygdala blunting effect in participants with anxiety or depression was consistent across each decision-making trial type. APP = approach–reward trial; AV = avoid–threat trial; CONF2 = conflict trial with a 2-cent reward; CONF4 = conflict trial with a 4-cent reward; CONF6 = conflict trial with a 6-cent reward.