Table 5. Distribution of sedation levels of patients in both groups .

		*Groups
		Placebo		Melatonin		Total
Time points	State	n	%	n	%	n	%
a Sedation score at base	1	12	40.0	1	3.30	13	21.70
	2	13	43.30	16	53.30	29	48.30
	3	5	16.70	10	33.30	15	25.0
	4	0	0.0	3	10.0	3	5.0
	5	0	0.0	0	0.0	0	0.0
	6	0	0.0	0	0.0	0	0.0
a Sedation score at 1h	1	11	36.70	2	6.70	13	21.70
	2	11	36.70	18	60.0	29	48.30
	3	8	26.70	9	30.0	17	28.30
	4	0	0.0	1	3.30	1	1.7
	5	0	0.0	0	0.0	0	0.0
	6	0	0.0	0	0.0	0	0.0
a Sedation score at 2h	1	7	23.30	2	6.70	9	15.0
	2	10	33.30	24	80.0	34	56.70
	3	13	43.30	4	13.30	17	28.30
	4	0	0.0	0	0.0	0	0.0
	5	0	0.0	0	0.0	0	0.0
	6	0	0.0	0	0.0	0	0.0
Sedation score at 6h	1	14	46.70	2	6.70	16	26.70
	2	16	53.30	22	73.30	38	63.30
	3	0	0.0	6	20.0	6	10.0
	4	0	0.0	0	0.0	0	0.0
	5	0	0.0	0	0.0	0	0.0
	6	0	0.0	0	0.0	0	0.0
Sedation score at 12h	1	16	53.3	0	0.0	16	26.7
	2	14	46.7	21	70.0	35	58.3
	3	0	0.0	9	30.0	9	15.0
	4	0	0.0	0	0.0	0	0.0
	5	0	0.0	0	0.0	0	0.0
	6	0	0.0	0	0.0	0	0.0
Sedation score at 24h	1	3	10.0	3	10.0	6	10.0
	2	25	83.3	25	83.3	50	83.3
	3	1	3.3	2	6.7	3	5.0
	4	0	0.0	0	0.0	0	0.0
	5	1	3.3	0	0.0	1	1.7
	6	0	0.0	0	0.0	0	0.0

^a The chi-square (Fisher exact test) is significant at the.05 level.

Interpretation note: percent is related to column for each time point.

^*Reading example: A state of sedation of 21.7% of all patients was 1 at baseline.

Sedation state: 1) anxious or restless; 2) cooperative, aware and calm; 3) responds to command; 4) responds quickly to stimulus; 5) responds slowly to strong stimulus; 6) unresponsive