. Author manuscript; available in PMC: 2022 Sep 6.

Published in final edited form as: Mol Cell Endocrinol. 2020 May 12;518:110860. doi: 10.1016/j.mce.2020.110860

Table 3.

Application of the key characteristics for EDCs to DDT

Key Char	Description	Evidence for DDT
KC1	interacts with or activates hormone receptors	Yes, ER
KC2	antagonizes hormone receptors	Yes, androgen receptor
KC3	alters hormone receptor expression	Yes, in female reproductive tissues
KC4	alters signal transduction in hormone-responsive cells	Yes, in mammary cells
KC5	induces epigenetic modifications in hormone-producing or hormone-responsive cells
KC6	alters hormone synthesis	Yes, via aromatase
KC7	alters hormone transport across cell membranes
KC8	alters hormone distribution or circulating hormone levels	Yes, androgens
KC9	alters hormone metabolism or clearance
KC10	alters fate of hormone-producing or hormone-responsive cells	Yes, in mammary gland