Table 3.
Patient and hospital characteristics by GEP testing for early-stage, HR+, HER2−, and LN− female breast cancer.
| GEP Testing | P value | ||
|---|---|---|---|
| Yes | No | ||
| (N = 3069) | (N = 3657) | ||
| N (Row %) | N (Row %) | ||
| Rural-urban residence | |||
| Urban | 1820 (47.2) | 2039 (52.8) | 0.013 a |
| Large rural | 421 (44.0) | 537 (56.0) | |
| Small rural | 828 (43.4) | 1081 (56.6) | |
| Hospital location | |||
| Urban | 2589 (47.2) | 2899 (52.8) | <0.0001 a |
| Large rural | 370 (43.4) | 483 (56.6) | |
| Small rural | 110 (28.6) | 275 (71.4) | |
| Age at diagnosis, years | |||
| <50 | 582 (61.6) | 362 (38.4) | <0.0001 b |
| 50–59 | 933 (61.1) | 593 (38.9) | |
| 60–69 | 1052 (50.2) | 1045 (49.8) | |
| ≥70 | 502 (23.2) | 1657 (76.8) | |
| Marital status at diagnosis | |||
| Married/Living with partner | 2156 (48.8) | 2260 (51.2) | <0.0001 a |
| Otherc/Unknown | 913 (39.5) | 1397 (60.5) | |
| Insurance status | |||
| Insuredd | 2769 (45.4) | 3333 (54.6) | 0.055a |
| Any Medicaide | 196 (51.3) | 186 (48.7) | |
| Uninsured/Unknown | 104 (43.0) | 138 (57.0) | |
| Median household income | |||
| <$50,000 | 708 (41.7) | 989 (58.3) | 0.001 b |
| $50,000-$59,999 | 879 (45.6) | 1048 (54.4) | |
| $60,000-$69,999 | 709 (47.1) | 797 (52.9) | |
| ≥$70,000 | 773 (48.4) | 823 (51.6) | |
| Year of diagnosis | |||
| 2010–2012 | 811 (42.1) | 1116 (57.9) | <0.0001 b |
| 2013–2015 | 977 (42.8) | 1306 (57.2) | |
| 2016–2018 | 1281 (50.9) | 1235 (49.1) | |
| Cancer stage | |||
| I | 2462 (45.2) | 2980 (54.8) | 0.188a |
| II | 607 (47.3) | 677 (52.7) | |
| Histology | |||
| Ductal | 2364 (46.7) | 2694 (53.3) | <0.0001 a |
| Lobular | 379 (48.0) | 411 (52.0) | |
| Ductal + Lobular | 148 (53.0) | 131 (47.0) | |
| Mucinous | 56 (25.9) | 160 (74.1) | |
| NOS/Other | 122 (31.9) | 261 (68.1) | |
| Tumor size, cm | |||
| 0.6–1.9 | 2273 (44.4) | 2851 (55.6) | <0.0001 b |
| 2.0–4.0 | 725 (51.5) | 683 (48.5) | |
| >4.0 | 71 (36.6) | 123 (63.4) | |
| Tumor grade | |||
| Well differentiated | 1032 (39.2) | 1600 (60.8) | <0.0001 a |
| Moderately differentiated | 1498 (50.6) | 1461 (49.4) | |
| Poorly differentiated/Undifferentiated | 495 (49.0) | 515 (51.0) | |
| Unknown | 44 (35.2) | 81 (64.8) | |
Abbreviations: CM, centimeter; GEP, gene expression profiling; HER2−, human epidermal growth factor receptor 2 negative; HR+, hormone receptor-positive; LN−, lymph node negative; NOS, not otherwise specified. Bold values indicate significance at α = 0.05. aP-values are based on Pearson chi-square test for categorical variables. bP-values are based on Cochran-Mantel-Haenszel test for trend for ordered variables. c Divorced, separated, single, and widowed. d Private insurance and Medicare. e Indian Health Service.