Table 4.
Odds of receiving GEP testing among women with early-stage, HR+, HER2−, LN− breast cancer.
| Unadjusted | Adjusted | |
|---|---|---|
| OR (95% CI) | ORa (95% CI) | |
| Hospital location | ||
| Urban | Ref | Ref |
| Large rural | 0.86 (0.74–0.99) | 1.05 (0.89–1.24) |
| Small rural | 0.45 (0.36–0.57) | 0.55 (0.43–0.71) |
| Age at diagnosis, years | ||
| <50 | Ref | Ref |
| 50–59 | 0.98 (0.83–1.16) | 1.04 (0.88–1.23) |
| 60–69 | 0.63 (0.54–0.74) | 0.66 (0.56–0.78) |
| ≥70 | 0.19 (0.16–0.22) | 0.20 (0.17–0.24) |
| Marital status | ||
| Married/Living with partner | Ref | Ref |
| Otherb/Unknown | 0.68 (0.62–0.76) | 0.87 (0.77–0.97) |
| Insurance status | ||
| Insuredc | Ref | Ref |
| Any Medicaidd | 1.27 (1.03–1.56) | 1.00 (0.80–1.26) |
| Uninsured/Unknown | 0.91 (0.70–1.17) | 0.78 (0.59–1.03) |
| Median household income | ||
| <$50,000 | Ref | Ref |
| $50,000-$59,999 | 1.18 (1.03–1.34) | 1.15 (0.99–1.32) |
| $60,000-$69,999 | 1.25 (1.08–1.44) | 1.17 (1.01–1.37) |
| ≥$70,000 | 1.32 (1.15–1.51) | 1.09 (0.94–1.32) |
| Year of diagnosis | ||
| 2010–2012 | Ref | Ref |
| 2013–2015 | 1.04 (0.92–1.17) | 1.00 (0.87–1.14) |
| 2016–2018 | 1.43 (1.27–1.61) | 1.47 (1.29–1.68) |
| Histology | ||
| Ductal | Ref | Ref |
| Lobular | 1.05 (0.91–1.22) | 1.15 (0.97–1.35) |
| Ductal + Lobular | 1.29 (1.01–1.64) | 1.29 (1.00–1.68) |
| Mucinous | 0.40 (0.29–0.54) | 0.53 (0.38–0.74) |
| NOS/Other | 0.54 (0.43–0.68) | 0.61 (0.48–0.78) |
| Tumor size, cm | ||
| 0.6–1.9 | Ref | Ref |
| 2.0–4.0 | 1.34 (1.19–1.50) | 1.29 (1.13–1.47) |
| >4.0 | 0.72 (0.54–0.97) | 0.54 (0.39–0.75) |
| Tumor grade | ||
| Well differentiated | Ref | Ref |
| Moderately differentiated | 1.59 (1.43–1.77) | 1.61 (1.43–1.81) |
| Poorly differentiated/Undifferentiated | 1.49 (1.29–1.73) | 1.32 (1.12–1.56) |
| Unknown | 0.84 (0.58–1.22) | 0.79 (0.53–1.17) |
Abbreviations: CI, confidence interval; CM, centimeter; GEP, gene expression profiling; HER2−, human epidermal growth factor receptor 2 negative; HR+, hormone receptor-positive; LN−, lymph node negative; NOS, not otherwise specified; OR, odds ratio; Ref, reference. Bold values indicate significance at α = 0.05. aAdjusted for all other variables in the table. bDivorced, separated, single, and widowed. c Private insurance and Medicare. d Indian Health Service. Bold values indicate significance at α = 0.05.