Figure 3.

Selected mechanisms of targeted lipid therapies. Current approaches to interventions that modify lipid metabolism include targeting genomic DNA, messenger RNA, or proteins. The strategies available include various strategies ranging from traditional small-molecule medicinal chemistry approaches through biological agents such as monoclonal antibodies, RNA therapeutics, and, on the horizon, gene editing. ApoC-III, apolipoprotein C-III; Lp(a), lipoprotein(a); HMG-CoA, hydroxymethylglutaryl coenzyme A; PCSK9, proprotein convertase subtilisin/kexin type 9.