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. 2022 Aug 11;25(9):1149–1162. doi: 10.1038/s41593-022-01131-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 7 — a-c, UMAP projection representing single-cell transcriptomes, with cells colored based on (a) the percentage of mitochondrial transcripts, (b) the expressed sgRNAs, with sgRNAs targeting CDK8 in orange, sgRNAs targeting TGFBR2 in blue, non-targeting control sgRNAs (NTC) in green, and all other sgRNAs in grey, or (c) expression levels of SOX2 (Left) or CSF1R (Right). d, Distribution of iTF-Microglia expressing non-targeting (NTC) sgRNAs across the 9 clusters described in Fig. 6. e, f,the top 40 genes with the highest embedding values for (e) the first principal component (PC-1) and (f) the second principal component (PC-2), displayed in ranking order.