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. 2022 Aug 11;25(9):1149–1162. doi: 10.1038/s41593-022-01131-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 8 — Changes in gene expression in response to CRISPRi knockdown of genes of interest in iTF-Microglia. Each column represents one CRISPRi-targeted gene. For each CRISPRi-targeted gene, cells with the strongest knockdown were selected and the top 20 differentially expressed genes in comparison to non-targeting control (NTC) sgRNA containing cells were selected. The merged set of these genes is represented by the rows. Rows and columns were clustered hierarchically based on Pearson correlation. Functionally related clusters of differentially expressed genes are labeled.