Table 2.

Overview of software packages compliant with ASL-BIDS. An asterisk indicates extensive testing with 51 non-public, clinical datasets from a variety of ASL techniques.

Tool/Software	Description	Available at
ASL processing software packages
ASLDRO30	Open source tool to generate BIDS-compliant simulated ASL digital reference object data. Raw ASL time series comprising control, label and M0 volumes are synthesized from ground truth images according to configurable acquisition and labelling parameters.	https://github.com/gold-standard-phantoms/asldro
ASL-MRICloud31	Cloud based tool for processing ASL data. It supports processing of single and multi-PLD data and NIfTI input. JSON and ASL-BIDS are currently not supported.	https://braingps.mricloud.org
ASLPrep32	ASL data preprocessing and cerebral blood flow computation pipeline, designed for easy accessibility, state-of-the art interface, and robustness to acquisition variations. BIDS and ASL-BIDS are supported.	https://aslprep.readthedocs.io/en/latest/index.html
ASLtoolbox33,34	One of the first Matlab toolboxes for processing ASL data. It contains a graphical user interface and processes single and multi-PLD data. It accepts input in NIfTi, but does not support JSON or ASL-BIDS.	https://cfn.upenn.edu/zewang/ASLtbx.php
BASIL35	Toolbox within the FMRIB Software Library providing the tools to analyze ASL datasets with quantification based on Bayesian inference principles. The toolbox accepts both single- and multi-PLD, and also Time-encoded and vessel-selective ASL data in NIfTI-format. Support for ASL-BIDS is in development.	https://asl-docs.readthedocs.io/en/latest/
*ExploreASL4	ExploreASL an SPM-based toolbox for processing, statistical analysis, and quality control of ASL datasets. ExploreASL fully supports ASL-BIDS input.	exploreasl.org; https://github.com/ExploreASL/ExploreASL

All listed tools are free for non-commercial use.